The study involves Positron Emission Tomography (PET) and Magnetic Resonance Imaging (MRI) imaging of the brain. PET and MRI brain imaging is performed before and after 8 weeks of NSAID treatment. This medication is FDA approved as an anti-inflammatory and may be effective to treat depression, especially if other treatments have failed. During treatment, you will be provided with free clinical appointments. Throughout the study, you will be interviewed about your physical and emotional health.